Reference Report

Reference
Citation	Thierry-Mieg, D. (1982). Paralog, a control mutant in Drosophila melanogaster. Genetics 100(): 209--237. (Export to RIS)
FlyBase ID	FBrf0038033
Publication Type	Research paper
PubMed ID	6809528
PubMed Abstract	The genetic properties of a pleiotropic mutant mapping at 1.4 +/- 0.1 in band 3B3 or its adjacent interbands on the X chromosome are described. The mutation is expressed autonomously in germ line cells, where it is recessive and has antimorphic properties. At 29 degrees, the mutation blocks oocyte differentiation, causing female sterility. At lower temperatures, it disturbs the maternal information in the egg; as a result, the progeny lack germ line cells (grandchildless phenotype) and exhibit defects of the cuticular pattern. The mutation is also expressed in somatic cells through zygotic interactions with neighboring regions, including 3A2, 3A3 (zeste), 3C1-2, 3C4 and 3C6-8 (Notch). We interpret the data by postulating that the expression of sets of dispersed genes might be controlled by the local topology of the chromosome, itself constrained by pairing of dispersed repeated elements. We call the mutation paralog.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (16)
	Df(1)62g18 Df(1)64c4 Df(1)64f1 Df(1)64j4 Df(1)65j26 Df(1)K95 Df(1)N-8 Df(1)N-264-105 Df(1)TEM7 Df(1)w258-11 Df(1)w258-42 Df(1)w258-45 Df(1)w-rJ1 Df(1)X12 Dp(1;2;Y)w⁺ Dp(1;2)w⁺70h
Alleles (17)
	crm⁷ dwg⁸ l(1)3Bb⁴ l(1)3Bb⁵ l(1)3Bc² l(1)3Bc³ l(1)3Bc⁴ l(1)3Bd² l(1)3Bf⁷ N^264-39 N^spl-1 par^X1122 Su(par)¹ trol¹³ v²⁴ w^a z^a
Genes (26)
	crm dwg egh fs(1)Ya fs(1)Yb gt l(1)3Ag l(1)3Ah l(1)3Bb l(1)3Bc l(1)3Bd l(1)3Bf mit(1)15 N par per rst sgg Su(par) tko trol v vt w wds z