Reference Report

Reference
Citation	Kidd, S., Lockett, T.J., Young, M.W. (1983). The Notch locus of Drosophila melanogaster. Cell 34(): 421--433.
FlyBase ID	FBrf0039003
Type of publication	Research paper
Offprint Available	Yes
External Crossreferences
PubMed ID	6193889
PubMed Abstract	The Notch locus appears to correspond to a 37 kb transcription unit. Homologous poly(A)+ RNA is about 11.7 kb. Nine RNA coding regions have been detected and localized within the transcription unit by S1 nuclease analyses. These range in size from 130 to 7250 bp. Sequences within the 3' coding region are variably used. Twenty-four Notch locus "point" mutations have been examined. Seven are associated with DNA insertions. Four insertions are associated with dominant mutations and are located within or very near RNA coding sequences of the 37 kb transcription unit. Three insertions are associated with recessive mutations and fall within intervening sequences. The positions of all insertions agree with the genetic map. It is estimated that, in the Notch region, one map unit corresponds to approximately 275 kb. On this basis, most of the 17 mutations that were not associated with DNA insertions can be placed within coding sequences of the 37 kb transcription unit.
Biosis	77034978
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Language of publication	English
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Abbreviation	Cell
Title	Cell
Authors
Volume range	1-
Year range	1974-
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Publisher	Cell Press
Place of publication	Cambridge, MA
Language of publication	English
ISBN/ISSN	0092-8674
CODEN	CELLB5
Data from Reference
Aberrations (3)
	Df(1)N-62b1 Df(1)N-66i25 Df(1)N-68f19
Alleles (11)
	N^264-109 N^264-40 N^55e11 N^Ax-S N^S N^l1N-1 N^l1N-2 N^l1N-3 N^l1N-B N^nd-1 N^nd-2
Genes (2)
	N opa-e
Natural transposons (1)
	flea