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Reference
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| Citation |
Artavanis-Tsakonas, S., Muskavitch, M.A., Yedvobnick, B. (1983). Molecular cloning of Notch, a locus affecting neurogenesis in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 80(): 1977--1981. |
| FlyBase ID |
FBrf0040118 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
6403942 |
| PubMed Abstract |
The Notch locus is one of the best characterized loci in Drosophila melanogaster in terms of its genetic structure and developmental
effects. Mutations in this locus profoundly affect the differentiation of the early embryo. Using an inversion involving the
Notch locus and previously cloned sequences, we have isolated chromosomal segments from the Notch region (3C7) encompassing
80 kilobases (kb) of DNA. Based on comparison between mutant and wild-type DNA, we have positioned cloned sequences within
the Notch genetic map; furthermore, we have defined a region of approximately 40 kb within which the structural lesions correlating
with all Notch alleles mapped to date appear to reside. We have examined the transcriptional activity of the cloned sequences
during ontogeny and find a single size class of poly(A)+ RNA, 10.5 kb long, that is homologous to sequences within this 40-kb
region. We conclude that DNA sequences belonging to the Notch locus have been cloned and that the 10.5-kb poly(A)+ RNA is
essential for wild-type Notch function. We discuss these structural and transcriptional data in light of the existing genetic
and developmental characterization of the Notch locus.
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| Biosis |
77027044 |
| Zoological record |
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Associated Information
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| Comments |
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| Text of personal communication |
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Related Publications
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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| Place of publication |
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Published In
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| Abbreviation |
Proc. Natl. Acad. Sci. USA |
| Title |
Proceedings of the National Academy of Sciences of the United States of America |
| Authors |
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| Volume range |
1- |
| Year range |
1915- |
| Page range |
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| Publisher |
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| Place of publication |
Washington, DC |
| Language of publication |
English |
| ISBN/ISSN |
0027-8424 |
| CODEN |
PNASA6 |
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Data from Reference
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| Aberrations (10)
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| Alleles (11)
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| Genes (3)
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