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Reference Report
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| Citation | Johnson, D.H., Friedman, T.B. (1983). Purine-resistant Drosophila melanogaster result from mutations in the adenine phosphoribosyltransferase structural gene. Proc. Natl. Acad. Sci. U.S.A. 80(): 2990--2994. (Export to RIS) | ||
| FlyBase ID | FBrf0040122 | ||
| Publication Type | Research paper | ||
| PubMed ID | 6407004 | ||
| PubMed Abstract | Mutants of Drosophila melanogaster selected for resistance to purine killing are deficient in adenine phosphoribosyltransferase (APRT; E.C. 2.4.2.7) activity. Genetic mapping and complementation analysis demonstrate that purine resistance, deficiency of APRT activity, and differences in the isoelectric point of APRT result from alterations at a single locus, Aprt (map position, 3:3.03). The level of APRT activity shows gene dose dependence in Aprt heterozygotes and in flies that are haploid for different Aprt alleles. Drosophila APRT is a dimer composed of apparently identical 23,000-dalton subunits. These results suggest that Aprt contains the structural gene for APRT. | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Proc. Natl. Acad. Sci. U.S.A. | ||
| Title | Proceedings of the National Academy of Sciences of the United States of America | ||
| Publication Year | 1915- | ||
| ISBN/ISSN | 0027-8424 | ||
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Data from Reference
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| Aberrations (10)
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| Alleles (7)
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| Genes (3)
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