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Reference
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| Citation |
Reddy, P., Zehring, W.A., Wheeler, D.A., Pirrotta, V., Hadfield, C., Hall, J.C., Rosbash, M. (1984). Molecular analysis of the period locus in Drosophila melanogaster and identification of a transcript involved in biological
rhythms. Cell 38(): 701--710. |
| FlyBase ID |
FBrf0040494 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
6435882 |
| PubMed Abstract |
We have isolated and analyzed DNA sequences encompassing the period (per) locus of Drosophila melanogaster. The location of
this clock gene was delimited by the molecular mapping of chromosome aberrations at or very near the per locus. At least five
RNAs are transcribed from this region. One of these transcripts, a 0.9 kb species, is strongly implicated in per's control
of biological rhythms. Two independently isolated arrhythmic mutations at the per locus dramatically reduce the level of this
transcript. Furthermore, the level of the 0.9 kb transcript is strongly modulated during a light/dark cycle. We discuss evidence,
from previously reported genetic and phenotypic analysis of per's function, suggesting that this region may be complex and
that several gene products from the per region, including this 0.9 kb transcript, may be involved in the different aspects
of normal rhythmicity influenced by this clock gene.
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Associated Information
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| Text of personal communication |
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Related Publications
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
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Published In
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| Abbreviation |
Cell |
| Title |
Cell |
| Authors |
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| Volume range |
1- |
| Year range |
1974- |
| Page range |
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| Publisher |
Cell Press |
| Place of publication |
Cambridge, MA |
| Language of publication |
English |
| ISBN/ISSN |
0092-8674 |
| CODEN |
CELLB5 |
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Data from Reference
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| Aberrations (8)
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| Alleles (3)
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| Genes (6)
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