Reference Report

Reference
Citation	Campuzano, S., Carramolino, L., Cabrera, C.V., Ruiz-Gomez, M., Villares, R., Boronat, A., Modolell, J. (1985). Molecular genetics of the achaete-scute gene complex of D. melanogaster. Cell 40(): 327--338.
FlyBase ID	FBrf0042024
Type of publication	Research paper
Offprint Available	Yes
External Crossreferences
PubMed ID	3917860
PubMed Abstract	The achaete-scute gene complex (AS-C), involved in differentiation of the sensory chaetes of D. melanogaster, and the yellow locus have been cloned. The yellow locus is the most distal and is followed, proximally, by the achaete and the scute loci. In the scute locus (75 kb), three transcription units separated by long stretches of DNA give rise to poly(A)+ RNAs of 1.6, 1.2, and 1.6 kb. Most DNA lesions associated with scute mutations map within the presumably untranscribed DNA. Their mutant phenotypes are stronger the closer the lesions are to the structural gene of one transcript (T4 RNA). Genetic and developmental data suggest that only this RNA is fundamental for the scute function. Its transcription might be perturbed by far removed DNA lesions. A second transcript is probably implicated in the lethal of scute embryonic function, while the third transcript is unnecessary for the differentiation of most macrochaetes. Two additional polyadenylated RNAs are transcribed from the achaete (1.1 kb) and yellow (1.9 kb) loci.
Biosis	79095066
Zoological record
Associated Information
Comments
Text of personal communication
Associated files
Related Publications

Also Published As

Other Reference Information
Secondary IDs
Language of publication	English
Additional language(s) of abstract
ISBN
Place of publication
Published In
Abbreviation	Cell
Title	Cell
Authors
Volume range	1-
Year range	1974-
Page range
Publisher	Cell Press
Place of publication	Cambridge, MA
Language of publication	English
ISBN/ISSN	0092-8674
CODEN	CELLB5
Data from Reference
Aberrations (24)
	Df(1)ase-1 Df(1)sc10-1 Df(1)sc⁶ Dp(1;3)sc^J4 In(1)ac³ In(1)sc^260-14 In(1)sc^260-22 In(1)sc²⁹ In(1)sc⁴ In(1)sc^4Lsc^9R In(1)sc⁷ In(1)sc⁸ In(1)sc⁹ In(1)sc^L8 In(1)sc^S1 In(1)sc^V2 In(1)y^3P In(1)y⁴ T(1;2)sc^S2 T(1;3)sc^260-15 T(1;3)sc^J4 T(1;3)sc^KA8 T(1;4)sc^H Tp(1;2)sc¹⁹
Alleles (29)
	ac¹ ac³ ac^3B sc¹⁷⁴⁴ sc¹⁹ sc¹ sc^260-14 sc^260-15 sc^260-22 sc²⁹ sc^3B sc⁴ sc⁵ sc⁶ sc⁷ sc⁸ sc⁹ sc^Ac sc^D1 sc^D2 sc^H sc^KA8 sc^L3 sc^L8 sc^S1 sc^V2 y¹ y² y⁴
Genes (7)
	Cyp4g1 ac ase l(1)sc pcl sc y
Insertions (10)
	?{}sc¹⁷⁴⁴ ?{}sc^Ac gypsy{}ac^3B gypsy{}sc¹ gypsy{}sc^3B gypsy{}sc^D1b gypsy{}sc^D2 gypsy{}sc^L3 gypsy{}y² jockey{}sc^D1a