Reference Report

Reference
Citation	Maine, E.M., Salz, H.K., Cline, T.W., Schedl, P. (1985). The Sex-lethal gene of Drosophila: DNA alterations associated with sex-specific lethal mutations. Cell 43(): 521--529. (Export to RIS)
FlyBase ID	FBrf0042036
Publication Type	Research paper
PubMed ID	3000609
PubMed Abstract	Genomic DNA encoding Sex-lethal, a developmental switch gene in Drosophila melanogaster that regulates sex determination and dosage compensation has been isolated. Wild-type DNA sequence organization of the gene has been compared at the restriction level with those of 17 female-specific, loss-of-function and five male-specific, gain-of-function mutant alleles. DNA lesions associated with 12 of these mutations delimit an 11 kb DNA region that is necessary for proper Sex-lethal function in females. Males who are deleted for this region are both viable and fertile. Loss-of-function alleles are associated with gross DNA alterations as well as true point mutations; the former are located throughout the region. In contrast, all five gain-of-function alleles are associated with DNA insertions that are clustered within a 1 kb portion of the Sxl gene region.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (8)
	Df(1)Sxl-nl Df(1)Sxl-ra Dp(1;1)jnR1-A Dp(1;1)jnR1-B Dp(1;3)sn^13a1 In(1)sc^S1Lsc^8R+dl-49 In(1)Sxl Tp(1;3)sn^13a1
Alleles (24)
	Sxl^f1 Sxl^f2 Sxl^f6 Sxl^f7,M1 Sxl^f9 Sxl^f10,M1 Sxl^f11,M1 Sxl^f37 Sxl^f58 Sxl^f2593 Sxl^fhv1 Sxl^fLS Sxl^fm1,M1 Sxl^fm6,M1 Sxl^fPb Sxl^M1,f3 Sxl^M1,fPa Sxl^M1,fPa-r1 Sxl^M1 Sxl^M1-vd1 Sxl^M2 Sxl^M3 Sxl^M4 Sxl^M5
Balancers (1)
	Binsinscy
Genes (2)
	l(1)7Aa Sxl
Insertions (8)
	?{}Sxl^f2 ?{}Sxl^fhv1 gypsy{}Sxl^fLS H{}Sxl^M5 P{}Sxl^fPb P{}Sxl^M1,fPa roo{}Sxl^M1 roo{}Sxl^M2
Natural transposons (3)
	gypsy P-element roo