Reference Report

Reference
Citation	Dura, J.M., Brock, H.W., Santamaria, P. (1985). Polyhomeotic: a gene of Drosophila melanogaster required for correct expression of segmental identity. Mol. Gen. Genet. 198: 213--220. (Export to RIS)
FlyBase ID	FBrf0043249
Publication Type	Research paper
PubMed ID	3920476
PubMed Abstract	A new locus in Drosophila melanogaster that is required for the correct expression of segmental identity has been discovered. The new locus, termed polyhomeotic (ph), is X-linked and maps cytologically to bands 2D2-3. Homozygous ph flies have homeotic transformations similar to those of known dominant gain of function mutants in the Antennapedia and bithorax complexes (ANT-C, BX-C), and in addition show loss of the humerus. ph interacts with three other similar mutations: Polycomb (Pc), Polycomblike (Pcl), and extra sex comb (esc), and acts as a dominant enhancer of Pc. The expression of ph depends on the ANT-C and BX-C dosage. ph has no embryonic phenotype, but temperature shift studies on ph2 show that the ph+ product is required during embryogenesis and larval development. We propose that ph mutants in some way disrupt the normal expression of the ANT-C and BX-C, and, therefore, that ph+ is needed for maintenance of segmental identity.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mol. Gen. Genet.
Title	Molecular and General Genetics
Publication Year	1967-2001
ISBN/ISSN	0026-8925
Data from Reference
Aberrations (16)
	Df(1)64c18 Df(1)Pgd-kz Df(1)ph⁴ Df(1)pn38 Df(1)w-vco Df(3R)P9 Df(3R)Scr Dp(1;2;Y)w⁺ Dp(1;3)w^vco Dp(1;f)R Dp(1;Y)dor18T Dp(3;3)D1 Dp(3;3)P5 In(1)pn⁴⁵ Tp(1;1)ph3 Tp(1;3)w^vco
Alleles (19)
	Abd-B^Mcp-1 Abd-B^Uab-1 Antp^B Antp^Hu Antp^Scx esc²⁰ Pc³ Pc^unspecified Pcl¹ ph-d¹ ph-d² ph-d⁴ ph-d⁹ ph-p³ ph-p⁷ rsc¹ Scr^Msc Ubx^Cbx-1 Ubx^Cbx-2
Genes (15)
	abd-A Abd-B Antp esc Pc Pcl Pgd ph-d ph-p pn rsc Scr Ubx y z