Open Close
Reference
Citation
DiNardo, S., O'Farrell, P.H. (1987). Establishment and refinement of segmental pattern in the Drosophila embryo: spatial control of engrailed expression by pair-rule genes.  Genes Dev. 1(): 1212--1225.
FlyBase ID
FBrf0046274
Publication Type
Research paper
Abstract

We are examining the development of the segmental body pattern of Drosophila by immunolocalization of engrailed, a developmental regulatory protein that maintains segmental subdivisions in the embryo, and is expressed in a spatially restricted (striped) manner that persists while the body pattern is being established and refined. A regulatory network among pair-rule segmentation genes establishes the striped pattern of engrailed expression. In general, mutations in particular pair-rule genes affect either even- or odd-numbered engrailed stripes. For example, fushi tarazu or odd-paired mutations delete even-numbered stripes, whereas paired mutations delete odd-numbered stripes. An analysis of engrailed expression in other mutants, including even-skipped odd-skipped double mutants, indicates that some pair-rule genes play a rule in establishing the correct width and position of engrailed stripes. Overall, the changes in engrailed pattern have consequences for final embryonic body pattern. Thus, the pair-rule loci, acting through engrailed, establish an early, general outline of body pattern. However, in several pair-rule mutants, engrailed patterns are dynamic, suggesting that as later events build upon this general rule to form the final body pattern, adjustments are made in response to the earlier pair-rule defect--that is, the pattern regulates.

PubMed ID
PubMed Central ID
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference
    Alleles (15)
    Genes (10)