Reference Report

Reference
Citation	Tomlinson, A., Kimmel, B.E., Rubin, G.M. (1988). rough, a Drosophila homeobox gene required in photoreceptors R2 and R5 for inductive interactions in the developing eye. Cell 55(): 771--784. (Export to RIS)
FlyBase ID	FBrf0047664
Publication Type	Research paper
PubMed ID	2903798
PubMed Abstract	The rough mutation in Drosophila disrupts an early stage of ommatidial assembly in the developing eye imaginal disc. Analysis of somatic mosaics suggests that rough gene function is required only in photoreceptors R2 and R5. However, these cells apparently differentiate normally in mutant eye discs and it is the cells that are subsequently added to the ommatidium that behave aberrantly. The rough gene was isolated by P-element transposon tagging, and the mutant can be rescued by transformation with an 8.6 kb genomic fragment. The rough transcription unit is 4.3 kb and consists of three exons that are joined in a 1.3 kb mRNA. The predicted rough protein is 350 amino acids long and contains a homeobox. Taken together, our results suggest that the role of the rough gene product may be to regulate the sending of signals by photoreceptors R2 and R5 to their neighbors in the developing ommatidia.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (4)
	Df(3R)Bd Df(3R)ro-XB3 Df(3R)ro-z1 Df(3R)Tl-Q
Alleles (5)
	ro¹ ro^+t8.6 ro^π13 ro^π13rv1 ry^+t7.2
Constructs (1)
	P{ro-8.6}
Genes (3)
	ro ry sev
Insertions (2)
	412{}ro¹ P{}ro^π13