|Citation||Lofquist, A.K., Garcia, A.D., Sharp, S.J. (1988). A discrete region centered 22 base pairs upstream of the initiation site modulates transcription of Drosophila tRNAAsn genes. Mol. Cell. Biol. 8(): 4441--4449. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||We have studied the mechanism by which 5'-flanking sequences modulate the in vitro transcription of eucaryotic tRNA genes. Using deletion and linker substitution mutagenesis, we have found that the 5'-flanking sequences responsible for the different in vitro transcription levels of three Drosophila tRNA5Asn genes are contained within a discrete region centered 22 nucleotides upstream from the transcription initiation site. In conjunction with the A-box intragenic control region, this upstream transcription-modulatory region functions in the selection mechanism for the site of transcription initiation. Since the transcription-modulatory region directs the position of the start site and the actual sequence of the transcription-modulatory region determines the level of tRNAAsn gene transcription, the possibility is raised that the transcription-modulatory region directs a transcription initiation event similar to open complex formation at procaryotic promoters.|
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|Language of Publication||English|
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|Abbreviation||Mol. Cell. Biol.|
|Title||Molecular and Cellular Biology|
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