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Citation
Schweisguth, F., Yanicostas, C., Payre, F., Lepesant, J.A., Vincent, A. (1989). cis-regulatory elements of the Drosophila blastoderm-specific serendipity gene: ectopic activation in the embryonic PNS promoted by the deletion of an upstream region.  Dev. Biol. 136(): 181--193.
FlyBase ID
FBrf0049479
Publication Type
Research paper
Abstract

The Drosophila serendipity alpha gene (sry alpha) is specifically expressed at the blastoderm stage in all somatic cells. By deletion analysis of sry alpha-lacZ fusion genes, the sry alpha cis-acting regulatory elements have been restricted to the [-311, +130] 5'-region of the gene and separated in two domains. The [-118, +130] domain is sufficient for transcriptional activation at the blastoderm stage. The [-311, -118] domain is required for a full level of expression. Deletion of this upstream domain leads to a secondary pattern of lacZ expression in precursor cells of the peripheral nervous system (PNS). The sry alpha gene is not itself secondarily expressed in the PNS, as shown by in situ hybridization. The patterns of expression of the different sry alpha-lacZ fusion genes suggest a combinatorial mode of regulation of sry alpha expression at blastoderm.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Biol.
    Title
    Developmental Biology
    Publication Year
    1959-
    ISBN/ISSN
    0012-1606
    Data From Reference
    Aberrations (1)
    Alleles (7)
    Genes (4)
    Sequence Features (2)
    Experimental Tools (1)
    Transgenic Constructs (5)
    Transcripts (2)