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Reference Report
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| Citation | Merrill, V.K., Diederich, R.J., Turner, F.R., Kaufman, T.C. (1989). A genetic and developmental analysis of mutations in labial, a gene necessary for proper head formation in Drosophila melanogaster. Dev. Biol. 135(): 376--391. (Export to RIS) | ||
| FlyBase ID | FBrf0049494 | ||
| Publication Type | Research paper | ||
| PubMed ID | 2570723 | ||
| PubMed Abstract | We have undertaken a developmental genetic analysis of labial (lab), the most proximal gene in the Antennapedia complex (ANT-C) of Drosophila melanogaster. The terminal phenotype of mutant embryos was examined in cuticle preparations, in thin sections, and by scanning electron microscopy. These preparations revealed a failure of head involution and the loss or disruption of several head structures, including the salivary glands and the H-piece and ventral arm of the cephalopharyngeal apparatus. Although these structures are presumed to derive from the gnathocephalic segments, we argue that the observed defects are likely to be a secondary consequence of a failure of head involution. A function for lab in the development of the adult head was inferred from the phenotype of animals bearing hypomorphic alleles and from clones of lab- tissue generated by mitotic recombination. Two aspects of the mutant phenotype were manifested. Ventrally, a deletion and/or disruption of tissue occurred in the maxillary palp and vibrissae regions. Dorsally, the posterior head appeared to be transformed to a thoracic-like identity. Mutations in lab, like those in the Deformed and proboscipedia loci of the ANT-C, reveal a homoeotic phenotype only in the adult stage of the life cycle. | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Dev. Biol. | ||
| Title | Developmental Biology | ||
| Publication Year | 1959- | ||
| ISBN/ISSN | 0012-1606 | ||
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Data from Reference
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| Aberrations (5)
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| Alleles (15)
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| Genes (11)
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