Reference Report

Reference
Citation	Rabinow, L., Birchler, J.A. (1989). A dosage-sensitive modifier of retrotransposon-induced alleles of the Drosophila white locus. EMBO J. 8: 879--889. (Export to RIS)
FlyBase ID	FBrf0049635
Publication Type	Research paper
PubMed ID	2542025
PubMed Abstract	The apricot allele of the white locus results from the insertion of the retrotransposon copia. Mutations in a newly discovered locus, the Darkener-of-apricot (Doa), suppress wa and some of its revertants. Of 44 other white alleles tested, only wsp55 is affected by Doa, although, in contrast, it is enhanced by Doa mutations. The Doa locus modulates wa and wsp55 expression as a function of its own dosage. Mutations in Doa are dominant suppressors or enhancers and are recessive lethals. Rare Doa mutant homozygotes escaping lethality demonstrate extreme phenotypic suppression of wa and enhancement of wsp55. RNA from wa is substantially wild-type in structure in escapers, although reduced in quantity.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	EMBO J.
Title	The EMBO Journal
Publication Year	1982-
ISBN/ISSN	0261-4189
Data from Reference
Aberrations (13)
	Dp(1;1)w⁺61e19 T(2;3)Doa¹⁰⁵ T(Y;3)B152 T(Y;3)B158 T(Y;3)B226 T(Y;3)R128 Tp(1;3)Doa^V53 Tp(3;2)Doa^CC Tp(3;3)Dfd^rv1 Ts(Y;3Rt)B152 Ts(YLt;3Rt)R128 Ts(YSt;3Rt)B158 Ts(YSt;3Rt)B226
Alleles (53)
	ct⁶ Doa³ Doa⁴ Doa⁵ Doa⁶ Doa⁷ Doa⁸ Doa⁹ Doa^HD f¹ ry^+t7.2 w¹ w¹¹¹⁸ w^+mF w^a2 w^a3 w^a4 w^a57i11 w^a58l w^a59k1 w^a w^aM w^apl w^aR84h w^bf2 w^bf w^bl w^Bwx w^cf w^co w^col w^e2 w^e w^E w^ec3 w^h wⁱ w^IR1 w^IR2 w^IR3 w^IR4 w^IR5 w^IR6 w^mo w^r w^sat w^sp1 w^sp2 w^sp4 w^sp55 w^sp81d w^zm y²
Constructs (3)
	?{} P{wE} P{wF}
Genes (10)
	ct Doa Dr e f Pr ry tx w y
Insertions (17)
	3S18{}w^a4 3S18{}w^zm ?{}w^aM copia{}w^a Doc{}w¹ gypsy{}ct⁶ gypsy{}f¹ gypsy{}y² I{407}w^IR3 I{}w^aR84h I{}w^IR1 I{}w^IR2 I{}w^IR4 I{}w^IR5 I{}w^IR6 roo{}w^bf roo{}w^sp1
Natural transposons (4)
	3S18 copia gypsy roo