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Citation
Parkhurst, S.M., Bopp, D., Ish-Horowicz, D. (1990). X:A ratio, the primary sex-determining signal in Drosophila, is transduced by helix-loop-helix proteins.  Cell 63(): 1179--1191.
FlyBase ID
FBrf0051358
Publication Type
Research paper
Abstract

Drosophila determines its sex by "counting" X chromosomes. We show that premature expression of the pair-rule segmentation gene hairy interferes with this process, resulting in female-specific lethality by inhibiting initiation of the master control gene Sex-lethal (Sxl). The female-specific lethality can be suppressed by a constitutive Sxl allele or by extra copies of X-linked "counting elements." These results are best explained by competition between hairy and other helix-loop-helix transcription factors that act in chromosome counting. We have confirmed this model by showing that misexpression of the achaete-scute T4 gene induces ectopic Sxl expression and male-specific lethality, confirming that achaete-scute T4 is the sisterless-b counting element. We propose that X chromosomes are counted through heterodimers of helix-loop-helix transcription factors that act synergistically to initiate Sxl expression.

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Related Publication(s)
Review

Monitor.
Anonymous, 1991, Trends Genet. 7(1): 6 [FBrf0099098]

Erratum

X:A ratio, the primary sex-determining signal in Drosophila, is transduced by helix-loop-helix proteins.
Parkhurst et al., 1991, Cell 64(5): following 1046 [FBrf0067276]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Aberrations (5)
    Alleles (5)
    Genes (10)
    Transgenic Constructs (4)