Open Close
Reference
Citation
Mlodzik, M., Hiromi, Y., Weber, U., Goodman, C.S., Rubin, G.M. (1990). The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates.  Cell 60(2): 211--224.
FlyBase ID
FBrf0051362
Publication Type
Research paper
Abstract

The Drosophila seven-up (svp) gene was isolated as a lethal insertion in an "enhancer trap" screen. It is expressed and required in photoreceptor cell precursors R1, R3, R4, and R6 during eye development. The absence of svp+ function causes a transformation of these cells toward an R7 cell fate, as judged by morphology and expression of an R7-specific marker. This transformation depends in part on the sevenless gene product. Our results show that svp is involved in control of cell fate during the generation of neuronal diversity. Molecular analysis of svp reveals that it is a member of the steroid receptor gene superfamily and is likely to be a Drosophila homolog of the human transcription factor COUP.

PubMed ID
PubMed Central ID
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
  • FBrf0049323
Language of Publication
English
Additional Languages of Abstract
Parent Publication
Publication Type
Journal
Abbreviation
Cell
Title
Cell
Publication Year
1974-
ISBN/ISSN
0092-8674
Data From Reference
Aberrations (5)
Alleles (7)
Genes (17)
Molecular Constructs (1)
Insertions (4)
Transgenic Constructs (2)