Reference Report

Reference
Citation	Elkins, T., Zinn, K., McAllister, L., Hoffmann, F.M., Goodman, C.S. (1990). Genetic analysis of a Drosophila neural cell adhesion molecule: interaction of fasciclin I and Abelson tyrosine kinase mutations. Cell 60(): 565--575. (Export to RIS)
FlyBase ID	FBrf0051382
Publication Type	Research paper
PubMed ID	2406026
PubMed Abstract	Drosophila fasciclin I is a homophilic cell adhesion molecule expressed in the developing embryo on the surface of a subset of fasciculating CNS axons, all PNS axons, and some nonneuronal cells. We have identified protein-null mutations in the fasciclin I (fas I) gene, and show that these mutants are viable and do not display gross defects in nervous system morphogenesis. The Drosophila Abelson (abl) proto-oncogene homolog encodes a cytoplasmic tyrosine kinase that is expressed during embryogenesis primarily in developing CNS axons; abl mutants show no gross defects in CNS morphogenesis. However, embryos doubly mutant for fas I and abl display major defects in CNS axon pathways, particularly in the commissural tracts where expression of these two proteins normally overlaps. The double mutant shows a clear defect in growth cone guidance; for example, the RP1 growth cone (normally fas I positive) does not follow its normal path across the commissure.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (8)
	Df(3L)E13 Df(3L)st-E36 Df(3L)X37 Df(3R)bxd100 Df(3R)P9 Df(3R)Ubx109 Tp(1;3)TE89Da Tp(3;3)bxd¹⁰⁰
Alleles (10)
	Abl¹ Abl² Abl^+tEa Fas1^+t23 Fas1^R3 Fas1^R9 Fas1^R18.1 Fas1^R40.1 Fas1^R2481 Fas1^TE89Da
Constructs (2)
	P{Abl^+tEa,Fas1^+tEa} P{fas1⁺}
Genes (10)
	Abl disco Egfr Fas1 Fas3 l(2)gl mys N Src64B zip