Open Close
Reference
Citation
Schweisguth, F., Lepesant, J.A., Vincent, A. (1990). The serendipity gene encodes a membrane-associated protein required for the cellularization of the Drosophila embryo.  Genes Dev. 4(): 922--931.
FlyBase ID
FBrf0051866
Publication Type
Research paper
Abstract

The Drosophila serendipity alpha (sry alpha) gene is specifically transcribed at the blastoderm stage, from nuclear cycle 11 to the onset of gastrulation, in all somatic nuclei. This pattern of transcription and a zygotic cellularization defect observed in embryos homozygous for Df(3R)X3F, a deficiency covering the sry locus, suggest that sry alpha plays a role in the cellularization of the syncytial blastoderm embryo. P-element rescue experiments show that one copy of the sry alpha gene rescues the defective cellularization phenotype associated with Df(3R)X3F. Lack of sry alpha activity results in erratic disruptions of the cytoskeleton at the beginning of the interphase of mitotic cycle 14. Multinucleate cells form during plasma membrane invagination. Immunodetection of the sry alpha protein using anti-sry alpha polyclonal antibodies indicates that the 58-kD sry alpha protein accumulates transiently at the blastoderm stage. The sry alpha protein is associated with the invaginating plasma membrane and colocalizes with F-actin. We propose that sry alpha is involved in the localization of membrane furrows within the syncytial blastoderm.

PubMed ID
PubMed Central ID
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference
    Aberrations (1)
    Alleles (7)
    Genes (7)
    Transgenic Constructs (3)