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Citation
Dushay, M.S., Konopka, R.J., Orr, D., Greenacre, M.L., Kyriacou, C.P., Rosbash, M., Hall, J.C. (1990). Phenotypic and genetic analysis of Clock, a new circadian rhythm mutant in Drosophila melanogaster.  Genetics 125: 557--578.
FlyBase ID
FBrf0051955
Publication Type
Research paper
Abstract

Clock is a semidominant X-linked mutation that results in shortening the period of Drosophila melanogaster's free-running locomotor activity rhythm from ca. 24.0 to ca. 22.5 hr. This mutation similarly shortened the phase response curve, determined by resetting activity rhythms with light pulses. Eclosion peaks for Clk cultures were separated by only 22.5 hr instead of the normal 24 hr. Clk was mapped close to, but separable from, another rhythm mutation--period01--by recombination. The estimated distance between these two mutations was short enough to suggest that Clk could be a per allele. If this is the case, the new mutant is unique in that it, unlike other per variants, is associated with essentially normal 1-min courtship song rhythms when Clk is expressed in males. Also, the new rhythm variant could not, in contrast to a short-period per mutation, have its effects on free-running activity rhythms uncovered by deletions. This result, and the lack of coverage of Clk's effects by duplications, suggest that it is not a simple hypomorphic or amorphic mutation.

PubMed ID
PubMed Central ID
PMC1204083 (PMC) (EuropePMC)
DOI
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Erratum

Phenotypic and genetic analysis of Clock, a new circadian rhythm mutant in Drosophila melanogaster.
Dushay et al., 1990, Genetics 126(2): 477 [FBrf0067250]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetics
    Title
    Genetics
    Publication Year
    1916-
    ISBN/ISSN
    0016-6731
    Data From Reference