Reference Report

Reference
Citation	Reuter, G., Giarre, M., Farah, J., Gausz, J., Spierer, A., Spierer, P. (1990). Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein. Nature 344(6263): 219--223. (Export to RIS)
FlyBase ID	FBrf0052637
Publication Type	Research paper
PubMed ID	2107402
PubMed Abstract	Position-effect variegation is the inactivation in some cells of a gene translocated next to heterochromatin, the region of the chromosome that is permanently condensed. The number of copies of the Drosophila gene Suvar(3)7 is a dose-limiting factor in this phenomenon, and seems from its sequence that it encodes a protein with five widely spaced zinc-fingers. This novel arrangement of zinc-fingers could help in packaging the chromatin fibre into heterochromatin, and also reflect a novel method of controlling the expression from DNA domains.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Aberrations (2)
	Df(3R)Ace-HD1 In(1)w^m4
Alleles (9)
	Pp1-87B¹ Su(var)2-1¹ Su(var)3-3³ Su(var)3-7^+t6.5 Su(var)3-7^+t10.4 Su(var)3-7^HH Su(var)3-7^SBPS Su(var)3-7^SP Su(var)3-8¹
Constructs (5)
	P{HH} P{RV-RV} P{SBPS} P{S-S} P{Su(var)SP}
Genes (6)
	Pp1-87B Su(var)2-1 Su(var)3-3 Su(var)3-7 Su(var)3-8 w