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Citation
Hardin, P.E., Hall, J.C., Rosbash, M. (1990). Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels.  Nature 343(6258): 536--540.
FlyBase ID
FBrf0052650
Publication Type
Research paper
Abstract

Mutations in the period (per) gene of Drosophila melanogaster affect both circadian and ultradian rhythms. Levels of per gene product undergo circadian oscillation, and it is now shown that there is an underlying oscillation in the level of per RNA. The observations indicate that the cycling of per-encoded protein could result from per RNA cycling, and that there is a feedback loop through which the activity of per-encoded protein causes cycling of its own RNA.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nature
    Title
    Nature
    Publication Year
    1869-
    ISBN/ISSN
    0028-0836
    Data From Reference
    Alleles (5)
    Genes (1)
    Transgenic Constructs (2)