A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Reference Report

Reference
Citation Gertler, F.B., Doctor, J.S., Hoffmann, F.M. (1990). Genetic suppression of mutations in the Drosophila abl proto-oncogene homolog.  Science 248(): 857--860. (Export to RIS)
FlyBase ID FBrf0052941
Publication Type Research paper
PubMed ID 2188361
PubMed Abstract The Drosophila abelson (abl) gene encodes the homolog of the mammalian c-abl cytoplasmic tyrosine kinase and is an essential gene for the development of viable adult flies. Three second-site mutations that suppress the lethality caused by the absence of abl function have been isolated, and all three map to the gene enabled (ena). The mutations are recessive embryonic lethal mutations but act as dominant mutations to compensate for the neural defects of abl mutants. Thus, mutations in a specific gene can compensate for the absence of a tyrosine kinase.
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Language of Publication English
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Publication Type Journal
Abbreviation Science
Title Science
Publication Year 1895-
ISBN/ISSN 0036-8075
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