Reference Report

Reference
Citation	Simon, M.A., Bowtell, D.D.L., Dodson, G.S., Laverty, T.R., Rubin, G.M. (1991). Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. Cell 67(23): 701--716. (Export to RIS)
FlyBase ID	FBrf0053392
Publication Type	Research paper
External Crossreferences
PubMed ID	1934068
PubMed Abstract	We have conducted a genetic screen for mutations that decrease the effectiveness of signaling by a protein tyrosine kinase, the product of the Drosophila melanogaster sevenless gene. These mutations define seven genes whose wild-type products may be required for signaling by sevenless. Four of the seven genes also appear to be essential for signaling by a second protein tyrosine kinase, the product of the Ellipse gene. The putative products of two of these seven genes have been identified. One encodes a ras protein. The other locus encodes a protein that is homologous to the S. cerevisiae CDC25 protein, an activator of guanine nucleotide exchange by ras proteins. These results suggest that the stimulation of ras protein activity is a key element in the signaling by sevenless and Ellipse and that this stimulation may be achieved by activating the exchange of GTP for bound GDP by the ras protein.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Editors
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (5)
	Df(2L)b80c1 Df(3R)by10 Df(3R)by62 In(3LR)TM3 Tp(3;2)by62
Alleles (30)
	Cdc37^e1C Cdc37^e1E Cdc37^e4D Cdc37^e6B csw^Esev1A-3EC csw^Esev1A-eOP drk^e0A E(sev)3D^e0Q Egfr^flb-Elp Hsp83^e1D Hsp83^e3A Hsp83^e4A Hsp83^e6A Hsp83^e6D Ras85D^+t12 Ras85D^e1B Ras85D^e2F ry^+t7.2 sev^B1 sev^B2 sev^B3 sev^B4 sev^B5 Sos^+t10 Sos^e0D Sos^e1A Sos^e2H Sos^e4G Sos^unspecified w^+mW.hs
Balancers (1)
	TM3-vSd
Constructs (12)
	P{Ras85D⁺12} P{sev^B1} P{sev^B2} P{sev^B3} P{sev^B4} P{sev^B5} P{Sos⁺10} pP{sev^B1} pP{sev^B2} pP{sev^B3} pP{sev^B4} pP{sev^B5}
Genes (11)
	Cdc37 csw drk E(sev)3D Egfr Hsp83 Ras85D ry sev Sos w
Insertions (2)
	P{sev^B4}A P{sev^B4}MS-1