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Reference
Citation	Klambt, C., Jacobs, J.R., Goodman, C.S. (1991). The midline of the Drosophila central nervous system: a model for the genetic analysis of cell fate, cell migration, and growth cone guidance. Cell 64(): 801--815.
FlyBase ID	FBrf0053395
Type of publication	Research paper
Offprint Available	Yes
External Crossreferences
PubMed ID	1997208
PubMed Abstract	A row of mesectodermal cells separates the two lateral neurogenic regions in the Drosophila embryo and generates a discrete set of glia and neurons. Most CNS growth cones initially head straight toward the midline, suggesting that these midline cells play a key role in the formation of the axon commissures. We have used antibodies that stain the first axons, beta-galactosidase enhancer trap lines that selectively stain the different midline cells, and electron microscopic studies to elucidate the cells and interactions that mediate the normal formation of the two major commissures in each segment. This analysis has led to a model that proposes a series of sequential cell interactions controlling the development of the axon commissures. A genetic test of this model has utilized a number of mutations that, by either eliminating or altering the differentiation of various midline cells, perturb the development of the axon commissures in a predictable fashion.
Biosis	91108041
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Language of publication	English
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Abbreviation	Cell
Title	Cell
Authors
Volume range	1-
Year range	1974-
Page range
Publisher	Cell Press
Place of publication	Cambridge, MA
Language of publication	English
ISBN/ISSN	0092-8674
CODEN	CELLB5
Data from Reference
Aberrations (3)
	In(1)FM7 In(2LR)O In(3LR)TM3
Alleles (17)
	Ecol\lacZ^56B Ecol\lacZ^AA142 Ecol\lacZ^AE60 Ecol\lacZ^AQ65 Ecol\lacZ^CK1 Ecol\lacZ^Q114 Ecol\lacZ^T13 Ecol\lacZ^X55 Ecol\lacZ^elav.PH Ecol\lacZ^en-AuI Ecol\lacZ^ftz.PH S¹ oc⁹ rho^7M43 sim² sli² spi¹
Balancers (5)
	CyO CyO-vKa FM7c FM7c-vHa TM3-vKc
Constructs (3)
	P{elav-lacZ.H} P{ftz/lacZ.H} P{lwB}
Genes (7)
	Ecol\lacZ S oc rho sim sli spi
Insertions (11)
	P{elav-lacZ.H}YH2 P{ftz/lacC}YH1 P{lwB}56B P{lwB}AA142 P{lwB}AE60 P{lwB}AQ65 P{lwB}CK1 P{lwB}Q114 P{lwB}T13 P{lwB}X55 P{lwB}en^AuI