Reference Report

Reference
Citation	Zuo, P., Stanojevic, D., Colgan, J., Han, K., Levine, M., Manley, J.L. (1991). Activation and repression of transcription by the gap proteins hunchback and Kruppel in cultured Drosophila cells. Genes Dev. 5(): 254--264. (Export to RIS)
FlyBase ID	FBrf0054055
Publication Type	Research paper
PubMed ID	1671661
PubMed Abstract	We have studied the ability of the Drosophila gap proteins Krüppel and hunchback to function as transcriptional regulators in cultured cells. Both proteins bind to specific sites in a 100-bp DNA fragment located upstream of the segment polarity gene engrailed, which also contains functional binding sites for a number of homeo box proteins. The hunchback protein is a strikingly concentration-dependent activator of transcription, capable of functioning both by itself and also synergistically with the pair-rule proteins fushi tarazu and paired. In contrast, Krüppel is a transcriptional repressor that can block transcription induced either by hunchback or by several different homeo box proteins. While repression of the homeo box protein activators requires a Krüppel-binding site on the DNA, repression of hunchback can occur efficiently in the absence of a Krüppel-binding site. We discuss the possible molecular mechanisms underlying these activities, as well as the potential significance of these results with respect to segmentation in Drosophila.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Alleles (19)
	Ecol\CAT^en.1k Ecol\CAT^en.2kI Ecol\CAT^en.2kIrr Ecol\CAT^en.3k Ecol\CAT^en.4kI Ecol\CAT^en.5k Ecol\CAT^en.kI Ecol\CAT^en.kII(90)kI Ecol\CAT^en.kII Ecol\CAT^hs.en.k Ecol\CAT^hs.en.rk Ecol\CAT^MtnA.PH ftz^Act5C.PH hb^Act5C.PZ Kr^Act5C.PZa Kr^Act5C.PZb prd^Act5C.PH zen2^Act5C.PH zen^Act5C.PH
Genes (8)
	Ecol\CAT en ftz hb Kr prd zen zen2
Sequence features (3)
	en-protein_bind-1 en-protein_bind-3 en-protein_bind-5