Reference Report

Reference
Citation	Moses, K., Rubin, G.M. (1991). Glass encodes a site-specific DNA-binding protein that is regulated in response to positional signals in the developing Drosophila eye. Genes Dev. 5(): 583--593. (Export to RIS)
FlyBase ID	FBrf0054063
Publication Type	Research paper
PubMed ID	2010085
PubMed Abstract	The glass gene encodes a zinc finger protein required for normal photoreceptor cell development in Drosophila. We show that glass transcripts are present in the third-instar eye-imaginal disc starting in the morphogenetic furrow and extending to the posterior margin of the disc; glass protein is detected in the nuclei of all cells in this region. We also show that glass encodes a site-specific DNA-binding protein. A 27-bp glass-binding site can confer glass-dependent expression on a reporter gene in developing photoreceptor cells, the particular subset of glass-expressing cells known to require glass function. This specificity may represent a regulation of glass protein activity after cells are recruited to the photoreceptor cell fate.
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Aberrations (1)
	T(2;3)gl^63d
Alleles (17)
	Ecol\lacZ^B.HZ50 Ecol\lacZ^D.HZ50 Ecol\lacZ^gl-B172 Ecol\lacZ^GMR.A.hs Ecol\lacZ^GMR.C.hs Ecol\lacZ^Hsp70Bb.HZ50 Egfr^E1 gl¹ gl² gl³ gl^60j gl^B27 gl^B172 ro^x63 ry^+t7.2 sca¹ sev¹⁴
Constructs (10)
	P{(-GMR)lacZ.B} P{(-GMR)lacZ.D} P{GMR-lacZ.A} P{GMR-lacZ.C(38.1)} pP{(-GMR)lacZ.B} pP{(-GMR)lacZ.D} pP{DM30hslacZ} pP{GMR-lacZ.A} pP{GMR-lacZ.C(38.1)} pUChsΔ2-3
Genes (8)
	Ecol\lacZ Egfr gl ninaE ro ry sca sev
Insertions (1)
	P{lacW}gl^B172
Sequence features (7)
	gl_constructA gl_constructC gl-protein_bind-1 gl-protein_bind-2 ninaE-protein_bind-3 ninaE-protein_bind-4 ninaE-protein_bind-5