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Reference
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| Citation |
Reaume, A.G., Knecht, D.A., Chovnick, A. (1991). The rosy locus in Drosophila melanogaster: xanthine dehydrogenase and eye pigments. Genetics 129(): 1099--1109. |
| FlyBase ID |
FBrf0054121 |
| Type of publication |
Research paper |
| Offprint Available |
No |
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External Crossreferences
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| PubMed ID |
1783294 |
| PubMed Abstract |
The rosy gene in Drosophila melanogaster codes for the enzyme xanthine dehydrogenase (XDH). Mutants that have no enzyme activity
are characterized by a brownish eye color phenotype reflecting a deficiency in the red eye pigment. Xanthine dehydrogenase
is not synthesized in the eye, but rather is transported there. The present report describes the ultrastructural localization
of XDH in the Drosophila eye. Three lines of evidence are presented demonstrating that XDH is sequestered within specific
vacuoles, the type II pigment granules. Histochemical and antibody staining of frozen sections, as well as thin layer chromatography
studies of several adult genotypes serve to examine some of the factors and genic interactions that may be involved in transport
of XDH, and in eye pigment formation. While a specific function for XDH in the synthesis of the red, pteridine eye pigments
remains unknown, these studies present evidence that: (1) the incorporation of XDH into the pigment granules requires specific
interaction between a normal XDH molecule and one or more transport proteins; (2) the structural integrity of the pigment
granule itself is dependent upon the presence of a normal balance of eye pigments, a notion advanced earlier.
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| Biosis |
93052389 |
| Zoological record |
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Associated Information
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| Comments |
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| Text of personal communication |
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Related Publications
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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| Place of publication |
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Published In
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| Abbreviation |
Genetics |
| Title |
Genetics |
| Authors |
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| Volume range |
1- |
| Year range |
1916- |
| Page range |
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| Publisher |
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| Place of publication |
Austin, TX, etc |
| Language of publication |
English |
| ISBN/ISSN |
0016-6731 |
| CODEN |
GENTAE |
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Data from Reference
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| Alleles (32)
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| Genes (14)
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