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Reference Report
| Reference | |||
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| Citation | O'Hare, K., Alley, M.R.K., Cullingford, T.E., Driver, A., Sanderson, M.J. (1991). DNA sequence of the Doc retroposon in the white-one mutant of Drosophila melanogaster and of secondary insertions in the phenotypically altered derivatives white-honey and white-eosin. Mol. Gen. Genet. 225: 17--24. (Export to RIS) | ||
| FlyBase ID | FBrf0054703 | ||
| Publication Type | Research paper | ||
| PubMed ID | 1705654 | ||
| PubMed Abstract | We analysed the structure of the white locus of Drosophila melanogaster in a family of related white mutants. The white-one mutant has bleach white eyes, and a Doc transposable element is inserted into the promotor region of the white locus. The DNA sequence of this Doc insertion was determined, and showed it to be closely related to other Drosophila melanogaster retroposons such as the I factor and the F, G and jockey elements. There are two long open reading frames, which encode a putative nucleic acid binding protein and a putative reverse transcriptase, respectively. Two independent, partially pigmented derivatives were analysed by cloning sequences from this region. In white-honey a transposable element of the retroviral class, B104, is inserted within the Doc element. In white-eosin there is an insertion within the Doc element of a 190 bp sequence that appears to be a member of a novel family of transposable elements. This pogo element is of the same structural class as the Drosophila melanogaster P and hobo elements. These data are consistent with the hypothesis that the Doc retroposon cannot excise, and that, for the white-one mutation, flies with altered phenotypes are most often generated by the insertion of additional transposable elements. | ||
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| Language of Publication | English | ||
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Parent Publication
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| Publication Type | Journal | ||
| Abbreviation | Mol. Gen. Genet. | ||
| Title | Molecular and General Genetics | ||
| Publication Year | 1967-2001 | ||
| ISBN/ISSN | 0026-8925 | ||
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Data from Reference
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| Alleles (7)
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| Genes (1)
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| Insertions (5)
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| Natural transposons (3)
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