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Reference
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| Citation |
de Valoir, T., Tucker, M.A., Belikoff, E.J., Camp, L.A., Bolduc, C., Beckingham, K. (1991). A second maternally expressed Drosophila gene encodes a putative RNA helicase of the 'DEAD box' family. Proc. Natl. Acad. Sci. USA 88(): 2113--2117. |
| FlyBase ID |
FBrf0054956 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
1900936 |
| PubMed Abstract |
Recently, a family of proteins containing the conserved motif Asp-Glu-Ala-Asp, the "DEAD box" proteins, has been identified.
This family is typified by the eukaryotic translation initiation factor eIF4A, and its members are believed to share the functional
property of ATP-dependent RNA unwinding. One of the previously identified members of this family (vasa) is the product of
a maternally expressed gene from Drosophila melanogaster that is known to play a role in the formation of the embryonic body
plan. We report here the isolation of a Drosophila gene that has an mRNA expression pattern somewhat similar to that of vasa
and also encodes a DEAD box protein. We have termed this gene ME31B to reflect its maternal (ovarian germ-line) expression
and its location within the 31B chromosome region. Comparisons with the other members of this family reveal that although
ME31B is most like the protein Tif1/Tif2, which probably represents the Saccharomyces cerevisiae version of eIF4A, it is unlikely
that ME31B represents the Drosophila eIF4A protein per se. A search for mutations in the ME31B gene has established that the
P element which causes the female-sterile mutation flipper lies in the 3' flank of the ME31B gene.
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| Biosis |
91118448 |
| Zoological record |
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Associated Information
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| Text of personal communication |
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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Published In
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| Abbreviation |
Proc. Natl. Acad. Sci. USA |
| Title |
Proceedings of the National Academy of Sciences of the United States of America |
| Authors |
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| Volume range |
1- |
| Year range |
1915- |
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| Publisher |
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| Place of publication |
Washington, DC |
| Language of publication |
English |
| ISBN/ISSN |
0027-8424 |
| CODEN |
PNASA6 |
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Data from Reference
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| Aberrations (4)
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| Alleles (1)
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| Genes (3)
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