|Citation||Matsuzaki, F., Koizumi, K., Hama, C., Yoshioka, T., Nabeshima, Y. (1992). Cloning of the Drosophila prospero gene and its expression in ganglion mother cells. Biochem. Biophys. Res. Commun. 182(3): 1326--1332. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||The Drosophila central nervous system comprises an enormous diversity of neurons that are originated from neuronal stem cells, neuroblasts. They generate a specific series of ganglion mother cells, each of which is once cleaved into a pair of neurons. Among genes known to control neurogenesis, prospero (pros) was recently identified as a gene required for gene expression specifying properties of some identified neurons. Here we report that pros encodes a nuclear protein containing a homeodomain-like sequence. In neuronal lineages of the central nervous system, pros protein is specifically detected in ganglion mother cells, although their parental neuroblasts have begun expressing a significant level of pros transcripts, suggesting a post-transcriptional control of pros expression. Our results provoke that in neuronal cell differentiation ganglion mother cells might play a pivotal role associating with the pros function.|
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|Language of Publication||English|
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|Abbreviation||Biochem. Biophys. Res. Commun.|
|Title||Biochemical and Biophysical Research Communications|
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