Reference Report

Reference
Citation	Gaul, U., Mardon, G., Rubin, G.M. (1992). A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase. Cell 68(): 1007--1019. (Export to RIS)
FlyBase ID	FBrf0055542
Publication Type	Research paper
PubMed ID	1547500
PubMed Abstract	A Drosophila gene with similarity to the mammalian Ras GTPase activating protein has been isolated in screens for mutations that affect eye development. Inactivation of the locus, Gap1, mimics constitutive activation of the Sevenless receptor tyrosine kinase and eliminates the need for a functional Sevenless protein in the R7 cell. Our results suggest that Gap1 acts as a negative regulator of signaling by Sevenless by down-regulating the activity of the Ras1 protein, which has been shown to be a key element in signaling by Sevenless.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (1)
	Df(3L)AC1
Alleles (12)
	boss¹ Ecol\lacZ^Gap1-rI533 Ecol\lacZ^Rh4.PF RasGAP1^B1 RasGAP1^B2 RasGAP1^B3 RasGAP1^B4 RasGAP1^B5 RasGAP1^rI533 RasGAP1^ΔPB1 sev¹⁴ sina²
Constructs (1)
	P{Rh4.1900lacZ}
Genes (7)
	boss Ecol\lacZ elav pum RasGAP1 sev sina
Insertions (1)
	P{PZ}RasGAP1^rI533
Libraries/Collections (1)
	TI_set_P{PZ}.BDGP