Reference Report

Reference
Citation	Furukawa, T., Maruyama, S., Kawaichi, M., Honjo, T. (1992). The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development. Cell 69(): 1191--1197. (Export to RIS)
FlyBase ID	FBrf0055544
Publication Type	Research paper
PubMed ID	1617729
PubMed Abstract	The J kappa RBP binds to the immunoglobulin recombination signal sequence flanking the kappa-type J segment. We previously isolated the highly conserved homolog of the J kappa RBP gene from D. melanogaster, which is not thought to have immunoglobulin molecules. Using many deficiency mutants and in situ hybridization, we mapped the Drosophila J kappa RBP gene in a region containing two recessive lethal mutations, i.e., br26 and br7, which shows the dominant Suppressor of Hairless (Su(H)) phenotype in heterozygotes. All six Su(H) alleles analyzed at the DNA level contained mutations in the Drosophila J kappa RBP gene. Since the Su(H) mutation affects peripheral nervous system development, the Drosophila J kappa RBP gene product is involved in gene regulation of peripheral nervous system development. The results also imply that the immunoglobulin recombination signal sequence and the target sequence of the Drosophila J kappa RBP protein might have a common evolutionary origin.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (18)
	Df(2L)64j Df(2L)A263 Df(2L)ARR1 Df(2L)b84a3 Df(2L)b84a7 Df(2L)b84h50 Df(2L)el28 Df(2L)fn5 Df(2L)osp29 Df(2L)rd9 Df(2L)TE35BC-7 Df(2L)TE35BC-28 Df(2L)TE35D-2 Df(2L)TE35D-6 Df(2L)TE35D-13 Df(2L)TE35D-15 Df(2L)TE35D-18 Df(3R)e-D7
Alleles (11)
	H¹ l(2)35Bg² Su(H)² Su(H)⁶ Su(H)⁸ Su(H)¹² Su(H)¹³ Su(H)¹⁴ Su(H)¹⁶ Su(H)^AM1 Su(H)^IB115
Genes (23)
	Adh ck Cul-3 CycE dyn-p25 esg H l(2)35Bc l(2)35Bd l(2)35Be l(2)35Bg l(2)35Cc l(2)35De l(2)35Df lace mol rd sna stc Su(H) TfIIS vas wor
Insertions (3)
	P{}Su(H)¹² P{}Su(H)¹³ P{}Su(H)¹⁴