Reference Report

Reference
Citation	Lee, J.J., Von Kessler, D., Parks, S., Beachy, P.A. (1992). Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog. Cell 71(): 33--50. (Export to RIS)
FlyBase ID	FBrf0055558
Publication Type	Research paper
PubMed ID	1394430
PubMed Abstract	The segment polarity genes engrailed and wingless are expressed in neighboring stripes of cells on opposite sides of the Drosophila parasegment boundary. Each gene is mutually required for maintenance of the other's expression; continued expression of both also requires several other segment polarity genes. We show here that one such gene, hedgehog, encodes a protein targeted to the secretory pathway and is expressed coincidently with engrailed in embryos and in imaginal discs; maintenance of the hedgehog expression pattern is itself dependent upon other segment polarity genes including engrailed and wingless. Expression of hedgehog thus functions in, and is sensitive to, positional signaling. These properties are consistent with the non-cell autonomous requirement for hedgehog in cuticular patterning and in maintenance of wingless expression.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (2)
	Df(2R)en-SFX31 Df(3R)4SCB
Alleles (16)
	Ecol\lacZ^hh-P30 en⁵⁸ eve^1.27 hh⁴ hh⁵ hh⁸ hh⁹ hh^A hh^AC hh^AE hh^AM hh^bar3 hh^P30 nkd² ptc⁹ wg^l-8
Genes (8)
	anon-94DEa Ecol\lacZ en eve hh nkd ptc wg
Insertions (5)
	P{?'PZ}hh^A P{?'PZ}hh^AC P{?'PZ}hh^AE P{?'PZ}hh^AM P{PZ}hh^P30