Reference Report

Reference
Citation	Alphey, L., Jimenez, J., White-Cooper, H., Dawson, I., Nurse, P., Glover, D.M. (1992). twine, a cdc25 homolog that functions in the male and female germline of Drosophila. Cell 69(2): 977--988. (Export to RIS)
FlyBase ID	FBrf0055587
Publication Type	Research paper
PubMed ID	1606618
PubMed Abstract	twine is the second homolog of the fission yeast gene cdc25 to be found in Drosophila. Both string and twine cDNAs can rescue a temperature-sensitive cdc25 mutation in fission yeast, but not a deletion. We detect the expression of string but not twine transcripts in the proliferating cells of newly cellularized embryos, in third instar larval brains, and in imaginal discs. Both genes are abundantly expressed in nurse cells during oogenesis, the maternal transcripts persisting throughout the syncytial stage of embryonic development. In the testis, twine transcripts are seen in the growing stage of premeiotic cysts. Analysis of a twine mutant suggests a requirement for the gene during oogenesis, during syncytial embryonic development, and for male meiosis. Meiosis does not occur in homozygous twine males, which produce cysts containing 16 rather than 64 spermatids.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (7)
	Df(2L)II30 Df(2L)osp29 Df(2L)RN2 Df(2L)Sco^rv16 Df(2L)TE35BC-24 In(2L)el18 Tp(2;2)A446
Alleles (3)
	twe¹ twe^+t3.7 twe^+t10
Constructs (2)
	P{twe⁺3.7} P{twe⁺10.0}
Genes (3)
	Spom\cdc25 stg twe