|Citation||Ho, Y.K., Guthrie, M.J., Clifford, A.J., Ho, C.C. (1992). Effect of adenine metabolites on survival of Drosophila melanogaster of low xanthine dehydrogenase activity. Comp. Biochem. Physiol. B. Comp. Bioch. 103: 413--417. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||1. Low xanthine dehydrogenase (LXD) mutant Drosophila melanogaster were fed 0.2% adenine for 7 generations, no adenine for the next 2 generations (relaxed) and 0.2% adenine again for the next 3 generations (rechallenged) to obtain adenine-resistant lines of Drosophila (LXD-adenine). Flies grown without adenine served as LXD-controls. 2. Purines ranked as follows; adenine > adenosine > AMP > inosine > IMP in decreasing order of toxicity to LXD-adenine flies. 3. Addition of ribose to 9N position, or phosphate or carboxy to 6C position of the purine ring alleviated the toxicity. 4. More LXD-adenine offspring survived than did LXD-control offspring rechallenged with adenine.|
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|Language of Publication||English|
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|Also Published As|
|Abbreviation||Comp. Biochem. Physiol. B. Comp. Bioch.|
|Title||Comparative Biochemistry and Physiology|
|Data from Reference|