Reference Report

Reference
Citation	Fischer-Vize, J.A., Rubin, G.M., Lehmann, R. (1992). The fat facets gene is required for Drosophila eye and embryo development. Development 116(): 985--1000. (Export to RIS)
FlyBase ID	FBrf0055917
Publication Type	Research paper
PubMed ID	1295747
PubMed Abstract	In a screen for mutations affecting Drosophila eye development, we have identified a gene called fat facets (faf) which is required for cell interactions that prevent particular cells in the developing eye from becoming photoreceptors. Analysis of eyes mosaic for faf+ and faf- cells shows that faf is required in cells near to, but outside, normal developing photoreceptors and also outside of the ectopic photoreceptors in mutant facets. faf is also essential during oogenesis, and we show that a faf-lacZ hybrid protein is localized via the first 392 amino acids of faf to the posterior pole of oocytes. Posterior localization of faf-lacZ depends on oskar. oskar encodes a key organizer of the pole plasm, a specialized cytoplasm at the posterior pole of embryos. The pole plasm is required for germ cell formation and contains the determinant of posterior polarity, encoded by nanos. Although other pole plasm components are required for localization of nanos RNA or for nanos protein function, faf is not. We have cloned the faf gene, and have shown that it encodes two similar large (approximately 300 x 10(3) M(r)) proteins that are unique with respect to other known proteins.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (4)
	Ab(3R;?)faf^BX9 Ab(3R;?)faf^BX13 Df(3R)faf-BP In(3R)faf^BX4
Alleles (28)
	faf^{392.T:Ecol\lacZ,T:Zzzz\nls1} faf^{392.T:Ecol\lacZ} faf^+t13 faf^+t14 faf^+t17 faf^B3 faf^B4 faf^B5 faf^B6 faf^B7 faf^B8 faf^BX1 faf^BX3 faf^BX4 faf^BX5 faf^BX6 faf^BX7 faf^BX8 faf^BX9 faf^BX10 faf^BX11 faf^BX13 faf^BX14 faf^BX15 faf^FBB12 faf^FO8 svp^AE127 w^+mW.hs
Constructs (6)
	P{fafI} P{fafII} P{fafIII} P{faf-lacZ.F} P{faf-lacZ.nls} pP{faf-lacZ.F}
Genes (5)
	faf svp T:Ecol\lacZ T:Zzzz\nls1 w
Insertions (1)
	P{lwB}svp^AE127