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Citation
Takahisa, M., Togashi, S., Ueda, R., Mikuni, M., Tsurumura, S., Kondo, K., Miyake, T. (1992). Structure of the Drosophila melanogaster gene encoding cyclin A.  Gene 121(): 343--346.
FlyBase ID
FBrf0056094
Publication Type
Research paper
Abstract
A P element (PE)-induced Drosophila melanogaster mutation, hari, affects the formation of the bristle mechanosensory organ in the adult fly. In this mutation, the site of PE insertion is in the first intron of the gene (CycA) encoding cyclin A (CycA). In order to analyze the hari mutant at the molecular level, we cloned and sequenced the cDNA and genomic DNA encoding CycA. CycA has seven exons and six introns, and its transcription unit spans 6 kb. All exon-intron junctions are compatible with the GT/AG consensus. Results of primer extension analysis and RNase protection assay indicate that CycA has major and minor transcription start points (tsp). To our knowledge, this is the first report on the CycA genomic sequence from a multicellular organism.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Gene
    Title
    Gene
    Publication Year
    1976-
    ISBN/ISSN
    0378-1119
    Data From Reference
    Alleles (1)
    Genes (1)
    Insertions (1)