Reference Report

Reference
Citation	Sinclair, D.A.R., Ruddell, A.A., Brock, J.K., Clegg, N.J., Lloyd, V.K., Grigliatti, T.A. (1992). A cytogenetic and genetic characterization of a group of closely linked second chromosome mutations that suppress position-effect variegation in Drosophila melanogaster. Genetics 130(): 333--344. (Export to RIS)
FlyBase ID	FBrf0056214
Publication Type	Research paper
PubMed ID	1541393
PubMed Abstract	Characterization of a group of dominant second chromosome suppressor of position-effect variegation (PEV) (Su(var)) mutants has revealed a variety of interesting properties, including: maternal-effect suppression of PEV, homozygous lethality or semilethality and male-specific hemizygous lethality, female infecundity, acute sensitivity to the amount of heterochromatin in the cell and sensitivity to sodium butyrate. Deficiency/duplication mapping and complementation tests have revealed that eight of the mutants define at least two genes in section 31 of the left arm of chromosome 2 and they suggest that a ninth corresponds to an additional nonessential Su(var) gene within or near this region. The effects of specific deficiencies and a duplication on PEV indicate that the expression of one or more of the Su(var) genes in this region of the chromosome is dose-dependent, i.e., capable of haplo-abnormal suppression and triplo-abnormal enhancement. Interestingly, the appearance of certain visible phenotypes among a subset of the mutants suggests that they may possess antimorphic properties. Our results are consistent with the hypothesis that two of these Su(var) genes encode structural components of heterochromatin. We also report that two previously isolated mutants located in 31E and 31F-32A act as recessive suppressors of PEV.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (12)
	Df(2L)J2 Df(2L)J27 Df(2L)J39 Df(2L)J77 Df(2L)J106 Df(2L)J233 Df(2R)M41A10 Dp(2;2)Mdh3 In(1)w^m4 In(2R)bw^VDe2 T(2;3)Sb^V T(Y;2)J^rv99
Alleles (11)
	abo¹ J^rv99 Su(var)2-1¹ Su(var)2-1²⁰⁷ Su(var)2-1^210-1 Su(var)2-1²¹³ Su(var)2-1²¹⁴ Su(var)2-1²¹⁵ Su(var)2-1²¹⁶ Su(var)204¹ Su(var)209¹
Genes (15)
	abo bw cdc2 da dal hup J pie RpS27A Sb Su(var)2-1 Su(var)204 Su(var)209 w wdl