Reference Report

Reference
Citation	Jack, J., DeLotto, Y. (1992). Effect of wing scalloping mutations on cut expression and sense organ differentiation in the Drosophila wing margin. Genetics 131(2): 353--363.
FlyBase ID	FBrf0056217
Type of publication	Research paper
Offprint Available	Yes
External Crossreferences
PubMed ID	1353736
PubMed Abstract	A number of wing scalloping mutations have been examined to determine their effects on the mutant phenotype of cut mutations and on the expression of the Cut protein. The mutations fall into two broad classes, those which interact synergistically with weak cut wing mutations to produce a more extreme wing phenotype than either mutation alone and those that have a simple additive effect with weak cut wing mutations. The synergistically interacting mutations are alleles of the Notch, Serrate and scalloped genes. These mutations affect development of the wing margin in a manner similar to the cut wing mutations. The mutations inactivate the cut transcriptional enhancer for the wing margin mechanoreceptors and noninnervated bristles and prevent differentiation of the organs. Surprisingly, reduction of Notch activity in the wing margin does not have the effect of converting epidermal cells to a neural fate as it does in other tissues of ectodermal origin. Rather, it prevents the differentiation of the wing margin mechanoreceptors and noninnervated bristles.
Biosis	94061643
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Language of publication	English
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Abbreviation	Genetics
Title	Genetics
Authors
Volume range	1-
Year range	1916-
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Place of publication	Austin, TX, etc
Language of publication	English
ISBN/ISSN	0016-6731
CODEN	GENTAE
Data from Reference
Aberrations (2)
	Df(1)sc10-1 T(2;3)ap^Xa
Alleles (13)
	Bx^J Ecol\lacZ^Hsp70Bb.HZ50 Ecol\lacZ^ct.wHZ N^264-40 N^nd-1 ap^Xa ct^46l ct^53d ct^L32 sc^10-1 sc¹ sd¹ sd²
Constructs (1)
	P{ctwHZ}
Genes (10)
	Bx Ecol\lacZ N Ser ac ap ct sc sd sens
Insertions (2)
	P{ctwHZ}2 roo{}ct^46l