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Reference
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| Citation |
Dambly-Chaudiere, C., Leyns, L. (1992). The determination of sense organs in Drosophila: a search for interacting genes. Int. J. Dev. Biol. 36(1): 85--91. |
| FlyBase ID |
FBrf0056376 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
1627479 |
| PubMed Abstract |
The determination of sense organs in Drosophila requires the concerted action of a battery of genes, several of which have
been identified. Previous experiments revealed that flies doubly heterozygous for mutations in two of these genes have a reduced
number of sense organs, suggesting the existence of a direct interaction between the corresponding genes and/or their products.
We have now used this observation to search for mutations in additional genes that would show similar interactions. We have
detected 10 recessive mutations that show a dominant reduction in the number of bristles when simultaneously heterozygous
for either Df(2)J27 or Df(4)M62f. Among these mutations, 3 are homozygous viable and show striking defects in their bristle
patterns, confirming that the genes thus identified play a role in the patterning of sense organs. We conclude that the "gene
dose titration" method (Botas et al., 1982) is an efficient method for identifying interacting genes involved in a common
process, provided one can identify a well-defined phenotype to look at, and at least one mutation that alters the process.
Our experience suggests that its efficiency should be substantially improved by the use of insertional mutagenesis.
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| Biosis |
94050454 |
| Zoological record |
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Associated Information
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| Comments |
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| Text of personal communication |
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Related Publications
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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| Place of publication |
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Published In
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| Abbreviation |
Int. J. Dev. Biol. |
| Title |
International Journal of Developmental Biology |
| Authors |
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| Volume range |
33- |
| Year range |
1989- |
| Page range |
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| Publisher |
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| Place of publication |
Vizcaya |
| Language of publication |
English |
| ISBN/ISSN |
0214-6282 |
| CODEN |
IJDBE5 |
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Data from Reference
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| Aberrations (6)
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| Alleles (19)
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| Genes (15)
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