Open Close
Reference
Citation
Germeraad, S.E., O'Dowd, D., Aldrich, R.W. (1992). Functional assay of a putative Drosophila sodium channel gene in homozygous deficiency neurons.  J. Neurogenet. 8(1): 1--16.
FlyBase ID
FBrf0056560
Publication Type
Research paper
Abstract

Using voltage-clamp techniques, we have examined embryonic sodium currents in neurons deficient for a gene located at 60E5/6 that shares extensive amino acid similarity with vertebrate sodium channel genes. These neurons expressed sodium currents similar to wildtype, supporting the hypothesis that para, and not the gene at 60E5/6, is the primary sodium channel gene expressed in embryonic neurons. A simple marking procedure allowing positive identification of the genotypes of cultured Drosophila embryos obtained from heterozygous parents was used to recognize cultures homozygous for deficiencies. The morphological development of both neurons and myotubes in these cultures was similar to wildtype, making it feasible to compare the properties of normal diploid cells and cells completely lacking a putative sodium channel gene.

PubMed ID
PubMed Central ID
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Neurogenet.
    Title
    Journal of Neurogenetics
    Publication Year
    1983-
    ISBN/ISSN
    0167-7063
    Data From Reference
    Aberrations (6)
    Alleles (3)
    Genes (7)
    Transgenic Constructs (1)