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Citation	Wainwright, S.M., Ish-Horowicz, D. (1992). Point mutations in the Drosophila hairy gene demonstrate in vivo requirements for basic, helix-loop-helix, and WRPW domains. Molec. Cell. Biol. 12(6): 2475--2483.
FlyBase ID	FBrf0057232
Type of publication	Research paper
Offprint Available	No
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PubMed ID	1588951
PubMed Abstract	The Drosophila pair-rule gene, hairy (h), encodes a nuclear basic helix-loop-helix (bHLH) protein that regulates embryonic segmentation and adult bristle patterning. In both cases, the h protein behaves as a transcriptional repressor. In this study, we determined the molecular nature of 12 h alleles. One mutation maps within the HLH domain, consistent with h function requiring homodimerization or heterodimerization with other HLH proteins. A second mutation lies in the basic domain, suggesting that DNA binding is required for h activity. Several mutations show that the h C terminus, in particular the WRPW domain, is also required for h activity, perhaps by interacting with other proteins to mediate transcriptional repression. We show that the h protein in Drosophila virilis closely resembles that in D. melanogaster and includes completely conserved bHLH and WRPW domains.
Biosis	94039507
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Language of publication	English
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Abbreviation	Molec. Cell. Biol.
Title	Molecular and Cellular Biology
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Volume range	1-
Year range	1981-
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Place of publication	Washington, DC
Language of publication	English
ISBN/ISSN	0270-7306
CODEN	MCEBD4
Data from Reference
Alleles (15)
	h¹ h²² h²⁴ h²⁵ h²⁶ h²⁷ h²⁹ h³⁰ h³¹ h⁴¹ h⁴ h^W15 h^W24 h^W4 hⁱ²²
Genes (13)
	Dvir\h E(spl) HLHm5 HLHm7 ac ase da dpn emc ftz h l(1)sc sc
Insertions (1)
	gypsy{}h¹