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Reference Report
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| Citation | Proust, J., Prudhommeau, C., Ladeveze, V., Gotteland, M., Fontyne-Branchard, M.C. (1992). I-R hybrid dysgenesis in Drosophila melanogaster. Use of in situ hybridization to show the association of I factor DNA with induced sex-linked recessive lethals. Mutat. Res. 268(): 265--285. (Export to RIS) | ||
| FlyBase ID | FBrf0057299 | ||
| Publication Type | Research paper | ||
| PubMed ID | 1379333 | ||
| PubMed Abstract | The purpose of this paper is the genetic visualization by in situ hybridization of 130 sex-linked recessive lethals plus a non-lethal induced by I-R dysgenesis. This collection of lethals involves inducer strains which differ in the position of the I elements on the X chromosomes. The I-R interaction was strong. Our previous results have shown that about 30% of the induced recessive lethals are associated with cytologically visible chromosomal rearrangements. (1) The rearrangements induced by I-R-type hybrid dysgenesis often exhibit homology with the I factor at the level of one or both junction points, depending on the types of chromosome rearrangements. These results suggest that the chromosome rearrangements arise directly from the transposition of I elements. However, the breakpoints of some types of cytologically non-visible deficiencies and of 2 small cytologically visible deficiencies do not present detectable homology with the I factor. (2) The majority of rearrangements do not involve the I elements already present on the paternal X chromosome. (3) The hybridization signal distributions on the X chromosome are not uniform. They present peaks of various heights which may correspond to specific anchoring areas of copies of I in the course of integration. (4) The data presented here agree with the literature with respect to the mean number of copies of I per X chromosome and to the excess of copies of I at locus 1A. Two rearrangement formation mechanisms are envisaged: crossing-over and 'target' exchanges. | ||
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| Language of Publication | English | ||
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Parent Publication
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| Publication Type | Journal | ||
| Abbreviation | Mutat. Res. | ||
| Title | Mutation Research | ||
| Publication Year | 1964- | ||
| ISBN/ISSN | 0027-5107 | ||
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Data from Reference
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| Aberrations (83)
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| Alleles (68)
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| Genes (41)
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| Insertions (23)
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