|Citation||Neufeld, E.J., Skalnik, D.G., Lievens, P.M.J., Orkin, S.H. (1992). Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut. Nat. Genet. 1(1): 50--55. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||Human CCAAT displacement protein (CDP), a putative repressor of developmentally regulated gene expression, was purified from HeLa cells by DNA binding-site affinity chromatography. cDNA encoding CDP was obtained by immunoscreening a lambda gt11 library with antibody raised against purified protein. The deduced primary amino acid sequence of CDP reveals remarkable homology to Drosophila cut with respect to the presence of a unique homeodomain and "cut repeats". As cut participates in determination of cell fate in several tissues in Drosophila, the similarity predicts a broad role for CDP in mammalian development.|
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|Language of Publication||English|
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