Reference Report

Reference
Citation	Struhl, G., Basler, K. (1993). Organizing activity of wingless protein in Drosophila. Cell 72(4): 527--540. (Export to RIS)
FlyBase ID	FBrf0057889
Publication Type	Research paper
PubMed ID	8440019
PubMed Abstract	The adult appendages of Drosophila are formed from imaginal discs, sheets of epithelial cells that proliferate during larval development and differentiate during metamorphosis. wingless (wg, DWnt-1) protein, a putative signaling molecule, is expressed only in prospective ventral cells in each of the leg discs. To test the role of wg, we have generated randomly positioned clones of cells that express wg protein constitutively. Clones that arise in the prospective ventral portions of the leg discs develop normally. In contrast, dorsally situated clones give rise to ventrolateral patterns and exert a ventralizing influence on neighboring wild-type tissue. We propose that wg protein organizes leg pattern along the dorsoventral axis by conferring ventral positional information within the disc.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (12)
	Ecol\lacZ^{Act5C.PS.T:Zzzz\nls1} Ecol\lacZ^{Scer\FRT.Act5C.T:Zzzz\nls1} Ecol\lacZ^{wg.T:Zzzz\nls1} Hsp70Ab^polyA phl^C20 ry^+t7.2 sc^Act5C.PS sc^{Scer\FRT.Act5C} Scer\FLP1^hs.PS wg^Act5C.PS wg^{Scer\FRT.Act5C} y^+t7.7
Constructs (43)
	001209 001210 001211 001212 001213 001214 001215 001216 001217 001218 001219 <FRT(J3) >FRT(J3) Act5C⁺0.4(Ns,Hp1) Act5C⁺0.7(HpaI,ATG) Act5C⁺0.7(tx,Ns) Act5C⁺4.4(R1,ATG) c20nx.mcs FRT-Hsp70Ab^polyA,phl^C20-FRT Hsp70Ab⁺0.4(R1,B) Hsp70Ab⁺2.1(S,R1) NheI P{Act5C(FRT.polyA)lacZ.nls1} P{Act5C(FRT.y⁺)sc.S} P{Act5C(FRT.y⁺)wg.S} P{Act5C(-FRT)lacZ.nls1} P{Act5C(-FRT)sc.S} P{Act5C(-FRT)wg.S} P{C20-Draf} P{C20NX} P{hsp70-flp} P{wg-lacZ.nls} pJ35 pP{Act5C(FRT.y⁺)wg.S} pP{C20NX} pP{hsp70-flp} pP{lacZ.FRT.S} pP{sc.FRT.S} pP{wg-lacZ.nls} unk.plasmid wg⁺1.6(Fn2,Ac) wg-αTub αTub84B⁺3'
Genes (9)
	Ecol\lacZ Hsp70Ab phl ry sc Scer\FLP1 T:Zzzz\nls1 wg y