Reference Report

Reference
Citation	Ebens, A.J., Garren, H., Cheyette, B.N.R., Zipursky, S.L. (1993). The Drosophila anachronism locus: a glycoprotein secreted by glia inhibits neuroblast proliferation. Cell 74(1): 15--27. (Export to RIS)
FlyBase ID	FBrf0057907
Publication Type	Research paper
PubMed ID	7916657
PubMed Abstract	The Drosophila anachronism (ana) locus controls the proliferation of neuroblasts, neuronal stem cells that give rise to the central nervous system. In ana mutants, quiescent postembryonic central brain and optic lobe neuroblasts enter S phase precociously. ana encodes a novel secreted protein of 474 amino acids that is expressed not in the affected neuroblasts, but rather in a subclass of neighboring glial cells. These studies argue for an important role for glia in negatively regulating proliferation of neuronal precursor cells, thereby controlling the timing of postembryonic neurogenesis.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (4)
	Df(2R)Np1 Df(2R)Np6 Df(2R)w45-31n Df(2R)w45-47n
Alleles (13)
	ana¹ ana² ana³ ana⁴ ana⁵ ana⁶ ana⁷ ana⁸ ana⁹ ana^+mEa ana^+t9.3 ana^hs.P Ecol\lacZ^ana.P
Constructs (3)
	P{ana⁺9.3} P{ana^+m} P{ana^hs.P}
Genes (2)
	ana Ecol\lacZ
Insertions (1)
	P{A92}ana¹
Transcripts (1)
	ana-RA