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Citation
Parkhurst, S.M., Lipshitz, H.D., Ish-Horowicz, D. (1993). achaete-scute feminizing activities and Drosophila sex determination.  Development 117(2): 737--749.
FlyBase ID
FBrf0058096
Publication Type
Research paper
Abstract

Sex determination in Drosophila depends on X-linked 'numerator' genes activating early Sex-lethal (Sxl) transcription in females. One numerator gene, sisterless-b (sis-b), corresponds to the achaete-scute (AS-C) T4 basic-helix-loop-helix (bHLH) gene. Two other closely related AS-C bHLH genes, T3 and T5, appear not to function as numerator elements. We analyzed endogenous AS-C expression and show that T4 is the major AS-C numerator gene because it is expressed earlier and more strongly than are T3 and T5. Only T4 expression is detectable during the early syncytial stages when Sxl state is being determined. Nevertheless, the effects of ectopic AS-C gene expression show that T3 and T5 proteins display weak but significant feminizing activities, enhancing male-lethality, and rescuing the female-lethality of sis mutations. Detailed examination of Sxl expression in rescued embryos suggests that female cells may be viable in the absence of detectable Sxl protein expression.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Development
    Title
    Development
    Publication Year
    1987-
    ISBN/ISSN
    0950-1991
    Data From Reference
    Aberrations (1)
    Alleles (9)
    Balancers (2)
    Genes (8)
    Insertions (1)
    Transgenic Constructs (5)