Reference Report

Reference
Citation	Jones, B., McGinnis, W. (1993). A new Drosophila homeobox gene, bsh, is expressed in a subset of brain cells during embryogenesis. Development 117(2): 793--806. (Export to RIS)
FlyBase ID	FBrf0058099
Publication Type	Research paper
PubMed ID	8101170
PubMed Abstract	Homeobox genes have been shown to control the determination of positional, tissue and cellular identity during the development of the fruitfly Drosophila melanogaster. Because genes involved in the determination of internal structures derived from neural, mesodermal and endodermal tissues may have been overlooked in conventional genetic screens, we undertook the identification of new homeobox genes expressed in these internal tissues. Here we describe the characterization of one of these new Drosophila homeobox genes, called brain-specific-homeobox (bsh). In embryos, bsh is expressed exclusively in the brain. bsh protein accumulates in approximately 30 cells in each brain hemisphere. One of these bsh expressing cells is closely associated with the terminus of the larval visual nerve (Bolwig's nerve). While deletions of chromosomal interval containing the bsh gene show no dramatic changes in embryonic brain morphology, the expression pattern of the bsh gene suggests that it may play a highly specialized role in the determination and function of cell type in the Drosophila brain.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (5)
	Df(2L)E55 Df(2L)OD16 Df(2L)pr65 Df(2L)TW65 Df(2L)TW161
Alleles (8)
	bsh^hs.PJ gl² l(2)37Fe¹ l(2)37Fg¹ scw⁵ scw^l1 spi^IIIM105 w^+mC
Constructs (1)
	P{hsp70-bsh}
Genes (7)
	bsh gl l(2)37Fe l(2)37Fg scw spi w