Open Close
Reference
Citation
Ruiz-Gomez, M., Ghysen, A. (1993). The expression and role of a proneural gene, achaete, in the development of the larval nervous system of Drosophila.  EMBO J. 12(3): 1121--1130.
FlyBase ID
FBrf0058134
Publication Type
Research paper
Abstract

The proneural genes of Drosophila are required for the segregation of neural precursors from the ectoderm. One of the proneural genes, achaete (ac), is responsible for the formation of a subset of larval and adult sense organs. We have examined the pattern of expression of ac and its regulation during embryogenesis. ac is expressed at particular locations of the ectoderm according to a highly dynamic and complex pattern. At each location the expression of ac occurs in two stages. First, ac is expressed in a cluster of cells ('competent' stage). This pattern of expression depends on an array of cis-regulatory sites which promote the expression of ac in clusters of cells at particular locations. Second, one cell of each cluster accumulates ac transcripts at a high level ('determined' stage) and becomes the neural progenitor cell. The restriction of the determined stage to one cell of the cluster requires the gene Notch. The transactivation of ac by sc (scute) or by other genes of the achaete-scute complex (AS-C) plays no role in defining the initial pattern of expression of ac, but might play a role in the shift from the competent to the determined level. We propose that the requirements of particular sense organs for different AS-C genes reflect the organization of this gene complex, rather than functional differences between the genes.

PubMed ID
PubMed Central ID
PMC413313 (PMC) (EuropePMC)
DOI
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO J.
    Title
    The EMBO Journal
    Publication Year
    1982-
    ISBN/ISSN
    0261-4189
    Data From Reference
    Aberrations (10)
    Alleles (11)
    Genes (6)
    Insertions (2)
    Transgenic Constructs (1)