Reference Report

Reference
Citation	Zhong, W., Sladek, F.M., Darnell, J.E. (1993). The expression pattern of a Drosophila homolog to the mouse transcription factor HNF-4 suggests a determinative role in gut formation. EMBO J. 12(2): 537--544. (Export to RIS)
FlyBase ID	FBrf0058163
Publication Type	Research paper
PubMed ID	8440243
PubMed Abstract	A Drosophila gene, HNF-4(D), was selected by cross-hybridization with a probe to rat HNF-4 (hepatocyte nuclear factor 4), a steroid hormone receptor super-family member that plays an important role in liver-specific gene expression. The Drosophila gene matched the mouse gene in 60 out of 66 amino acids in the zinc finger DNA binding domain and in 140 out of 206 amino acids in the domain that specifies dimerization and ligand binding. HNF-4(D) is expressed in developing Drosophila embryos in mid-gut, fat bodies and malpighian tubules, a striking similarity to its limited expression in the adult intestine, liver and kidney of the mouse. Furthermore, Drosophila mutant that has a chromosome deletion spanning the HNF-4(D) locus fails to develop tissues where HNF-4(D) is expressed during late embryogenesis. These findings together with the earlier realization that the rat hepatocyte nuclear factor 3 (HNF-3) and forkhead, a Drosophila gene required for anterior and posterior gut formation, had virtually the identical DNA binding domain, lead us to speculate that a group of genes that participate in gut formation of invertebrates has survived in evolution to perform similar functions in mammals.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	EMBO J.
Title	The EMBO Journal
Publication Year	1982-
ISBN/ISSN	0261-4189
Data from Reference
Aberrations (2)
	Df(2L)TE30Cb-1 In(2LR)SM6
Alleles (1)
	Ecol\lacZ^eve.8.0
Balancers (2)
	SM6b SM6Bevelac
Constructs (1)
	P{eve-lacZ8.0}
Genes (3)
	Ecol\lacZ fkh Hnf4
Insertions (1)
	P{eve-lacZ8.0}SB1